Oral Tofacitinib: Contemporary Appraisal of Its Role in Dermatology
Identifieur interne : 000569 ( Main/Exploration ); précédent : 000568; suivant : 000570Oral Tofacitinib: Contemporary Appraisal of Its Role in Dermatology
Auteurs : Sidharth Sonthalia ; Parul AggarwalSource :
- Indian Dermatology Online Journal [ 2229-5178 ] ; 2019.
Abstract
Tofacitinib, an oral Janus kinase inhibitor (Jakinib), is an emerging treatment modality whose well-established efficacy in systemic inflammatory diseases is now being actively explored for cutaneous disorders (arising due to the patient's dysimmune responses) that are not responding to and/or sustaining intolerable adverse effects with the classical immunosuppressives and other targeted therapies such as the biologics. The most common dermatoses for which oral as well as topical Jakinibs such as tofacitinib have been evaluated and are being used albeit as an off-label indication include psoriasis, psoriatic arthritis, alopecia areata, vitiligo, and atopic dermatitis. This article provides a succinct review on the current status of oral tofacitinib in dermatology through literature search of PubMed database and stresses on the need for further evidence generation to define the drug's place in the therapeutic arsenal of dysimmune cutaneous disorders.
Url:
DOI: 10.4103/idoj.IDOJ_474_18
PubMed: 31544068
PubMed Central: 6743407
Affiliations:
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<record><TEI><teiHeader><fileDesc><titleStmt><title xml:lang="en">Oral Tofacitinib: Contemporary Appraisal of Its Role in Dermatology</title><author><name sortKey="Sonthalia, Sidharth" sort="Sonthalia, Sidharth" uniqKey="Sonthalia S" first="Sidharth" last="Sonthalia">Sidharth Sonthalia</name><affiliation><nlm:aff id="aff1"></nlm:aff></affiliation></author><author><name sortKey="Aggarwal, Parul" sort="Aggarwal, Parul" uniqKey="Aggarwal P" first="Parul" last="Aggarwal">Parul Aggarwal</name><affiliation><nlm:aff id="aff2"><italic>Consultant Dermatologist, Department of Dermatology and STD, Skinalive Clinic, New Delhi, India</italic></nlm:aff></affiliation></author></titleStmt><publicationStmt><idno type="wicri:source">PMC</idno><idno type="pmid">31544068</idno><idno type="pmc">6743407</idno><idno type="url">http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6743407</idno><idno type="RBID">PMC:6743407</idno><idno type="doi">10.4103/idoj.IDOJ_474_18</idno><date when="2019">2019</date><idno type="wicri:Area/Pmc/Corpus">000A02</idno><idno type="wicri:explorRef" wicri:stream="Pmc" wicri:step="Corpus" wicri:corpus="PMC">000A02</idno><idno type="wicri:Area/Pmc/Curation">000A02</idno><idno type="wicri:explorRef" wicri:stream="Pmc" wicri:step="Curation">000A02</idno><idno type="wicri:Area/Pmc/Checkpoint">000520</idno><idno type="wicri:explorRef" wicri:stream="Pmc" wicri:step="Checkpoint">000520</idno><idno type="wicri:Area/Ncbi/Merge">000A41</idno><idno type="wicri:Area/Ncbi/Curation">000A41</idno><idno type="wicri:Area/Ncbi/Checkpoint">000A41</idno><idno type="wicri:doubleKey">2229-5178:2019:Sonthalia S:oral:tofacitinib:contemporary</idno><idno type="wicri:Area/Main/Merge">000569</idno><idno type="wicri:Area/Main/Curation">000569</idno><idno type="wicri:Area/Main/Exploration">000569</idno></publicationStmt><sourceDesc><biblStruct><analytic><title xml:lang="en" level="a" type="main">Oral Tofacitinib: Contemporary Appraisal of Its Role in Dermatology</title><author><name sortKey="Sonthalia, Sidharth" sort="Sonthalia, Sidharth" uniqKey="Sonthalia S" first="Sidharth" last="Sonthalia">Sidharth Sonthalia</name><affiliation><nlm:aff id="aff1"></nlm:aff></affiliation></author><author><name sortKey="Aggarwal, Parul" sort="Aggarwal, Parul" uniqKey="Aggarwal P" first="Parul" last="Aggarwal">Parul Aggarwal</name><affiliation><nlm:aff id="aff2"><italic>Consultant Dermatologist, Department of Dermatology and STD, Skinalive Clinic, New Delhi, India</italic></nlm:aff></affiliation></author></analytic><series><title level="j">Indian Dermatology Online Journal</title><idno type="ISSN">2229-5178</idno><idno type="eISSN">2249-5673</idno><imprint><date when="2019">2019</date></imprint></series></biblStruct></sourceDesc></fileDesc><profileDesc><textClass></textClass></profileDesc></teiHeader><front><div type="abstract" xml:lang="en"><p>Tofacitinib, an oral Janus kinase inhibitor (Jakinib), is an emerging treatment modality whose well-established efficacy in systemic inflammatory diseases is now being actively explored for cutaneous disorders (arising due to the patient's dysimmune responses) that are not responding to and/or sustaining intolerable adverse effects with the classical immunosuppressives and other targeted therapies such as the biologics. The most common dermatoses for which oral as well as topical Jakinibs such as tofacitinib have been evaluated and are being used albeit as an off-label indication include psoriasis, psoriatic arthritis, alopecia areata, vitiligo, and atopic dermatitis. This article provides a succinct review on the current status of oral tofacitinib in dermatology through literature search of PubMed database and stresses on the need for further evidence generation to define the drug's place in the therapeutic arsenal of dysimmune cutaneous disorders.</p></div></front><back><div1 type="bibliography"><listBibl><biblStruct><analytic><author><name sortKey="Shreberk Hassidim, R" uniqKey="Shreberk Hassidim R">R Shreberk-Hassidim</name></author><author><name sortKey="Ramot, Y" uniqKey="Ramot Y">Y Ramot</name></author><author><name sortKey="Zlotogorski, A" uniqKey="Zlotogorski A">A Zlotogorski</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Samadi, A" uniqKey="Samadi A">A Samadi</name></author><author><name sortKey="Ahmad Nasrollahi, S" uniqKey="Ahmad Nasrollahi S">S Ahmad Nasrollahi</name></author><author><name sortKey="Hashemi, A" uniqKey="Hashemi A">A Hashemi</name></author><author><name sortKey="Nassiri Kashani, M" 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Lacouture</name></author><author><name sortKey="Kheterpal, M" uniqKey="Kheterpal M">M Kheterpal</name></author></analytic></biblStruct></listBibl></div1></back></TEI><affiliations><list></list><tree><noCountry><name sortKey="Aggarwal, Parul" sort="Aggarwal, Parul" uniqKey="Aggarwal P" first="Parul" last="Aggarwal">Parul Aggarwal</name><name sortKey="Sonthalia, Sidharth" sort="Sonthalia, Sidharth" uniqKey="Sonthalia S" first="Sidharth" last="Sonthalia">Sidharth Sonthalia</name></noCountry></tree></affiliations></record>Pour manipuler ce document sous Unix (Dilib)
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